Toxines et antioxydants, Alzheimer
531, boulevard des Prairies
Laval (Québec) H7V 1B7
CANADA
Quelques publications avec comités de pairs
*: CR’s students.
57. PAKA, G. D. & RAMASSAMY, C. (2016) Optimization of curcumin loaded-PEG-PLGA nanoparticles by GSH functionalization. Investigation of the internalization pathway in neuronal cells,
Molecular Pharmaceutics, [article en pré-publication]
56. DJIOKENG PAKA, G., DOGGUI, S., ZAGHMI, A., SAFAR, R., DAO, L., REISCH, A., KLYMCHENKO, A., ROULLIN, V. G., JOUBERT, O. & RAMASSAMY, C. (2016) Neuronal Uptake and Neuroprotective Properties of Curcumin-Loaded Nanoparticles on SK-N-SH Cell Line: Role of Poly(lactide-co-glycolide) Polymeric Matrix Composition,
Molecular Pharmaceutics, 13, 2, 391-403
55. BELKACEMI, A. & RAMASSAMY, C. (2016) Anthocyanins Protect SK-N-SH Cells Against Acrolein-Induced Toxicity by Preserving the Cellular Redox State,
Journal of Alzheimer's Disease, 50, 4, 981-998
54. BELKACEMI, A. & RAMASSAMY, C. (2016)
Central Nervous System Agents in Medicinal Chemistry, 16, 1, 37-49
53. RABANEL, J. M., FAIVRE, J., PAKA, G. D., RAMASSAMY, C., HILDGEN, P. & BANQUY, X. (2015)
European Journal of Pharmaceutics and Biopharmaceutics, 96, 409-420
52. MOYSE, E., ARSENEAULT, M., GAUDREAU, P., FERLAND, G. & RAMASSAMY, C. (2015)
Mechanisms of Ageing and Development, 149, 19-30
51. CHEN, M., TAN, M., JING, M., LIU, A., LIU, Q., WEN, S., CHEN, Z., CHAO, X., HE, X., RAMASSAMY, C., GAO, Y. & PI, R. (2015)
Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway,
Metabolic Brain Disease, 30, 1, 137-42
50. CHAO, X. J., CHEN, Z. W., LIU, A. M., HE, X. X., WANG, S. G., WANG, Y. T., LIU, P. Q., RAMASSAMY, C., MAK, S. H., CUI, W., KONG, A. N., YU, Z. L., HAN, Y. F. & PI, R. B. (2014)
CNS Neuroscience & Therapeutics, 20, 9, 840-50
49. HUANG, Y. J., QIN, J., CHEN, M. H., CHAO, X. J., CHEN, Z. W., RAMASSAMY, C., PI, R. B. & JIN, M. H. (2014)
Lithium Prevents Acrolein-Induced Neurotoxicity in HT22 Mouse Hippocampal Cells,
Neurochemical Research, 39, 4, 677-684
48. M. Tan,Y. Ouyang, M Jin, M Chen, P Liu, X Chao, Z Chen, X Chen, C Ramassamy C,Y Gao, R Pi.
Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in Homocysteic acid-induced cytotoxicity in HT-22 cells.Toxicol Lett. 2013 Aug 27. S0378-4274(13) 01283-6.
47. S. Doggui, A. Belkacemi, G. Djiokeng Paka,M Perrotte, R. Pi and C. Ramassamy
Curcumin protects neuronal-like cells against acrolein by restoring Akt and redox signaling pathways. Mol. Nutr. & Food Res. 2013 Sep;57(9): 1660-70.
46. MSingh*, V Murthy, C Ramassamy.
Neuroprotective mechanisms of the standardized extract of Bacopa monniera in a paraquat/diquat-mediated acute toxicity. Neurochem Int.2013 Apr;62(5):530-9.
45. YJ Huang, MH Jin, RB Pi, JJ Zhang*, Y Ouyang, XJ Chao, MH Chen, PQ Liu, JC Yu , C Ramassamy, J Dou, XH Chen, YM Jiang, J Qin.
Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo. Toxicol Lett. 2013; 217(3):184-91.
44. Y. Huang, M. Jin, RB. Pi, J. Zhang*, M Chen, Y Ouyang, A Liu, X Chao, P Liu, J Liu, C Ramassamy, J Qin.
Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Neurosci Lett. 2013;535:146-51
43. S Doggui#, Lé Dao and C Ramassamy
Potential of drug-loaded nanoparticles for Alzheimer’s disease: diagnosis, prevention and treatment. Therapeutic Delivery 20123(9):1025-1027.
42. S Doggui*#, J K Sahni*#, M Arseneault, Lé Dao and C Ramassamy
Neuronal uptake and neuroprotective effect of curcumin-loaded PLGA nanoparticles on the human SK-N-SH cell line. J Alzheimers Dis. 201230(2):377-92
#: 1st co-author
41. ABelkacemi*, C Ramassamy
Time sequence of oxidative stress in the brain from transgenic mouse models of Alzheimer's disease related to the amyloid-βcascade. Free Radic Biol Med. 2012; 52(3):593-600.
40. M Singh*, Ven Murthy and C Ramassamy
Standardized extracts of Bacopa monniera protect against MPP+ and Paraquat induced- toxicities bymodulating mitochondrial activities, proteasomal functions and redox pathways. Toxcicol.Sci. 2012; 125(1):219-32.
39. ABelkacemi*, S Doggui*, L Dao and C Ramassamy
Challenges associated with curcumin therapy in Alzheimer’s disease. Expert. Rev. Molecular Med.2011; 13:e34. Review.
38.C. Ramassamy and A Belkacémi*
Nutrition and Alzheimer’s disease: is there any connection? Cur.Alz.Res. 2011; 8: 443-444
37. C. St-Laurent Thibault*, M. Arsenault*, and C. Ramassamy
Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against ß-amyloid toxicity. Involvement of the NF-kB signaling. Cur.Alz.Res 2011; 8:543-551
36. Dang Thanh*, M. Arseneault and C Ramassamy
Regulation of redox-sensitive signaling pathways in rat primary astrocytes following acrolein exposure. J Alzheimers Dis. 2011; 21:263-277
35. C Ramassamy, S Doggui*, L Dao
Nanoneuropharmacology: A challenging concept in pharmaceutical investigations for the next decade. Int J Pharma Investig 2011; 1:2-3
34. J K Sahni*, S Doggui*, J Ali, S Baboota, L Dao and C Ramassamy
Neurotherapeutic applications of Nanoparticles in Alzheimer’s disease. J.Control.Release (IF 7), June, 2011; 152(2):208-31
33. MSingh*, Dang Than N*, M Arseneault* and C Ramassamy
Role of by-product of lipid oxidation in Alzheimer’s disease: a focus on acrolein. J Alzheimers Dis. 2010 21(3):741-756, 2010.
32- N.Dang Than*, M Arseneault*, N Zarkovic, G Waeg and C. Ramassamy
Molecular Regulations Induced by Acrolein in Neuroblastoma SK-N-SH Cells: Relevance to Alzheimer's Disease. J Alzheimers Dis. 21, 1197–1216, 2010.
31. M.Singh*, V. Murthy and C. Ramassamy
Modulation of Hydrogen Peroxide and Acrolein-Induced Oxidative Stress, Mitochondrial Dysfunctions and Redox Regulated Pathways by the Bacopa Monniera Extract: Potential Implication in Alzheimer's Disease. J Alzheimers Dis. 21(1):229-247, 2010.
30- N.Dang Than*, M Arseneault*,MRV Murthy and C Ramassamy
Potential role of acrolein in neurodegeneration and in Alzheimer's Disease. Curr Mol Pharmacol. 3(2):66-78, 2010 (IF 3.46)
29. T. Vuong*, C. Matar, C. Ramassamy, P. S. Haddad,
Biotransformed blueberry juice protects neurons from hydrogen peroxide induced oxidative stress and MAPKs pathway alterations. Br.J.Nutr. 12:1-8, 2010
28. Ali J, Ali M, Baboota S, Sahni JK*, Ramassamy C, Dao L, Bhavna.
Potential of nanoparticulate drug delivery systems by intranasal administration. Curr Pharm Des. 2010 May;16(14):1644-53.
27. Fortier, M., Frouin, H., Cloutier*, A, Arseneault*, M., Ramassamy, C., Badiwa-Bizowe, B, St-Louis, R., Pelletier, E. and Michel Fournier.
Toxicological effects of mouse diet contaminated with TBT on the immune and neurological systems of c57bl/6 mice. Toxicol & Environmental Chem. 92(5): 927-945, 2010.
26- M.R. Ven Murthy, Prabhakar K. Ranjekar, C. Ramassamy, M. Deshpande et al.
Scientific basis for the use of Indian Ayurvedic medicinal plants in the treatment of neurodegenerative disorders. Central Nervous System Agents in Medicinal Chemistry (formerly''Current medicinal chemistry. Central nervous system agents'')10, 238-246, 2010
25- Vuong T*, Benhaddou-Andaloussi A, Brault A, Harbilas D, Martineau LC, Vallerand D, Ramassamy C, Matar C, Haddad PS.
Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKA(y) mice. Int J Obes. 33(10) : 1166-73, 2009
24. Owen JB, Opii WO, Ramassamy C, Pierce WM, Butterfield DA.
Proteomic analysis of brain protein expression levels in NF-kappabeta p50 (-/-) homozygous knockout mice. Brain Res. 1240: 22-30. 2008)
23- M. Singh*, M. Arseneault*, T. Sanderson, V. Murthy, and C. Ramassamy
Challenges for research on polyphenols in neurodegenerative diseases: Bioavailability, metabolism, cellular and molecular mechanisms. J.Agr.Food.Chem. 56(13): 4855-73. 2008
22- Tri Vuong*, Louis C. Martineau, C. Ramassamy, Chantal Matar, Pierre S. Haddad
Fermented Canadian lowbush blueberry juice (Vaccinium Angustifolium Ait.) stimulates glucose uptake and AMP-activated protein kinase (AMPK) in insulin-sensitive cultured muscle cells and adipocytes. Canadian J. Physiology and Pharmacol. 85(9):956-65, 2007
21- C. Ramassamy, F. Longpré* and Y. Christen*
Ginkgo biloba extract (EGb 761) in Alzheimer’s disease: is there any evidence? Current Alzheimer Res 4 (3), 253-262, 2007.
20- F. Longpré*, P.Garneau*, Y. Christen and C. Ramassamy
Protection by EGb 761 against the ß-amyloid induced-neurotoxicity: involvement of NF-kB, SIRT1 and MAPKs pathways and inhibition of the amyloid fibrils formation. Free Radical Biol.& Med . 41(12), 1781-1795, 2006
19- C. Ramassamy
Emerging role of polyphenolic compounds in the treatment of Alzheimer’s disease. Eur.J.Pharmacol. 545 (2006) 51–64
18- Gagne B, Gelinas S, Bureau G, Lagace B, Ramassamy C, Chiasson K, Valastro B, Martinoli MG.
Effects of estradiol, phytoestrogens, and Ginkgo biloba extracts against 1-methyl-4-phenyl-pyridine-induced oxidative stress. Endocrine. 2003, 21(1):89-95.
17- C. Ramassamy, P. Krzywkowski, D. Averill, U. Beffert, L. Theroux, S. Lussier-Cacan, J. Davignon, Y. Christen and J. Poirier.
Influence of the absence of apolipoprotein E on lipid oxidation: an age-related study on the apoE-deficient mice model. Mol.Brain Res .86(1-2):76-83, 2001
16- C.B. Patrick, P. Krzywkowski, C.Ramassamy, J. Poirier and E. Murphy.
Phospholipiase A2 Activity in the hippocampus of aged apolipoprotein E deficient mice. Neurosci. Let. 288: 211-214, 2000
15 - S. Bastianetto, C. Ramassamy, S. Doré, Y. Christen, J. Poirier and R. Quirion.
The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid. Eur. J. Neuroscience 12, 1882-1891, 2000
14- C. Ramassamy, D. Averill , U. Beffert, L. Theroux, S. Lussier-Cacan, J. Davignon, Y.Christen and J. Poirier.
Oxidative insults in Alzheimer's disease brain are associated to apolipoprotein E genotype. Neurobiol. Dis 7, 23-37, 2000
13- C. Ramassamy, D. Averill , U. Beffert, S. Lussier-Cacan, J. Davignon, Y. Christen and J. Poirier.
Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype. Free Rad.Biol.Med. 27, 544-553, 1999
12- U. Beffert, J. S. Cohn, C. Petit-Turcotte, M. Tremblay, N. Aumont, C. Ramassamy, J. Davignon and J. Poirier.
Apolipoprotein E and b-amyloid levels in the hippocampus and frontal cortex of Alzheimer’s disease subjects are disease-related and apolipoprotein E genotype dependent. Brain Res. 843, 87-94, 1999
11- S. Bastianetto, C. Ramassamy, J. Poirier and R. Quirion.
Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Mol.Brain Res. 66, 35-41, 1999
10- U. Beffert, M. Danik, P. Krzywkowski, C. Ramassamy, F. Berrada and J. Poirier.
The neurobiology of apolipoproteins and their receptors in the central nervous system and Alzheimer’s disease. Brain Research Rev. 27, 119-142, 1998
Guest editorial
3. M Singh* and C Ramassamy
Environmental exposure to pesticides and neurodegenerative diseases. J. Alzheimer’s Dis & Parkinsonism 2(3), 2-3, 2012.
2- C. Ramassamy, S Doggui*, L Dao
Nanoneuropharmacology: A challenging concept in pharmaceutical investigations for the next decade. J.Pharm.Investigation 1(1) (2011) 2-3,
1- Ramassamy C., Belkacémi A*.
Nutrition and Alzheimer's disease: is there any connection? Curr Alzheimer Res. 2011 8(5):443-4.
LIVRE: Recent research on nutrition and the prevention of Alzheimer's disease.
Scientific Editor: C. Ramassamy, editor: Research SignPost ISBN- 978-81-7895-470-7, 2010
Guest editor
Journal title: Current Alzheimer Research, hot topic issues on
“Nutrition and Alzheimer’s disease: is there any connection? (2010)
Guest editor: C.Ramassamy
Chapitres de livre
17.
Perrotte M*, Pincemail J, Haddad M*, C Ramassamy (Sous presse)
Redox based-peripheral biomarkers in Alzheimer’s disease : challenges, limits and prospects.
In: Oxidative Stress in Applied Basic Research and Clinical Practice. Scientific editors: S. Bondy and A Campbell. Editor: Springer
16. J K Sahni*, S. Doggui*, L.H. Dao, C. Ramassamy
Nanotechnology for cerebral delivery of nutraceuticals for the treatment of neurodegenerative diseases.
In: Nutraceuticals and neurodegenerative disease prevention. Scientific editors: Dr. Gopinadhan Paliyath, Dr. Marica Bakovic, Dr. Kalidas Shetty. Editor: Wiley-Blackwell, Iowa. 263-283, 2011.
15. J. K. Sahni*, L. Letenneur, L. H. Dao, C. Ramassamy
Antioxidants and diet approach as a potential neuroprotective strategy for Alzheimer’s disease with a focus on brain targets by polyphenols
In : Lifetime nutritional influences on cognition, behaviour and psychiatric illness. Scientific editor: David Benton, Editor: Woodhead Publishing. 392-419, 2011.
14. C. Ramassamy, M. Arseneault* and D Thanh Nam*
Free radical-mediated damages to brain in Alzheimer’s disease: Role of acrolein and preclinical promise of antioxidant polyphenols.
In: Oxidative Stress in Basic Research and Clinical Practice : Aging and Age-Related Disorders
Scientific editor: S.Bondy, Editor: Springer, 417-438. 2010
13- C. Ramassamy, S. Doggui*, M. Arsenault*and Lé Dao
Towards a nutritional approach for the prevention of Alzheimer’s disease: promise of polyphenolic components. In: Recent research on nutrition and the prevention of Alzheimer's disease. Chap. 1, pp.1-18, 2010.
Scientific Editor: C. Ramassamy, Editor: Research SignPost. ISBN 978-81-7895-470-7
12- M.Singh*, V.Murthy, M.Arseneault* and C. Ramassamy
Neuroprotective effects of polyphenols in Alzheimer’s disease: antioxidants activities and beyond.
In: New Research on Dietary Polyphenols & Health". Ed. Nova Science Publishers 113-15, 2008.
11- M.Singh* and C. Ramassamy
Beneficial effects of phenolic compounds from fruits and vegetables in neurodegenerative diseases.
In: Improving the health-promoting properties of fruit and vegetable products. Ed. Pr F. Tomás Barberán and Dr. María Isabel Gil, CEBAS CSIC, Spain (in press) Woodhead Publishing Limited, Cambridge UK. chapitre 7: 145-181, 2008.
Dans les médias
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// 25 septembre 2013
Explications du chercheur Docteur Rémi Quirion sur la maladie d'Alzheimer
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Prévenir et mieux traiter la maladie d'Alzheimer
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