27 septembre 2017
Centre INRS–Institut Armand-Frappier
Salle Pasteur, pavillon Édouard-Asselin
531, boul. des Prairies
Ouvert à tous
Places non limitées
Le Centre INRS–Institut Armand-Frappier vous invite à assister, dans le cadre des conférences Armand-Frappier, à la conférence de Hilde De Reuse, professeure agrégée au Département de microbiologie, Unité pathogenèse de Helicobacter à l'Institut Pasteur à Paris. La professeure Hilde De Reuse est l'invitée du professeur Frederic Veyrier.
Titre de la conférence
Evolution of Helicobacter and nickel metabolism
Metal acquisition and intracellular trafficking are crucial for all cells and metal ions have been recognized as virulence determinants in bacterial pathogens. Helicobacter pylori colonizes the acidic stomach of about half of the human population worldwide and is associated with gastric cancer that is responsible for 700,000 deaths every year. Virulence of Helicobacter pylori depends on the metal nickel, cofactor of two enzymes essential for in vivo colonization. In our group, we are studying the transport, storage and distribution of nickel in H. pylori. I will present the functional characterization of unique nickel-binding proteins of H. pylori that act as nickel stores and are essential for colonization. In addition, I will show our recent identification of a novel nickel transporter that is also required for colonization. Phylogenomics were applied to study the distribution of these proteins in the Helicobacter genus that is divided into two categories, enterohepatic species and gastric species (such as H. pylori) that exclusively colonize the stomach of mammals. Our data show that, during evolution of the Helicobacter genus, acquisition by gastric Helicobacter species of proteins involved in nickel transport and trafficking constituted a decisive evolutionary event to allow Helicobacter to colonize the hostile gastric environment and to become an amazingly successful pathogen.
Le café sera servi avant la conférence.